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KMID : 0606920150230060510
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Biomolecules & Therapeutics
2015 Volume.23 No. 6 p.510 ~ p.516
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Lipid A as a Drug Target and Therapeutic Molecule
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Joo Sang-Hoon
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Abstract
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In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
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KEYWORD
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Lipid A, Endotoxin, Drug target, Antibacterial, Adjuvant
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